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About CE-MS Interface Development
The field of CE-MS coupling is currently rapidly evolving. The established co-axial sheath solvent flow electrospray ionization interface method as introduced by Agilent Technologies (before Hewlett-Packard) is challenged by new sheathless or extremely low sheath flow sprayers published by Moini et al, Chen et al, Dovichi et al and Smith et al. with putative higher sensitivity. These novel approaches though are not yet offered commercially in a coherent, complete CE-MS system as Agilent Technologies does.
Agilent is challenging these competitive, new CE-MS coupling methods by improving all components of their current approach from the CE, the sprayer, and the MS to the software controlling the overall system rendering their system robust, reliable, and comparatively sensitive. Moreover, an extensive library of CE-MS AppNotes and a guidebook "CE/MS Principles and Practices, a guidebook for novices and practitioners" has been published. These exciting developments will eventually benefit all users and deliver a compelling argument for using CE as a separation technique for chemical analysis and bio-analytical measurements.